PerkinElmer Informatics at Booth #1316 at Fall ACS - San Francisco

by PerkinElmer Informatics17. July 2014 11:23

PerkinElmer is excited to be a part of the Fall 2014 American Chemical Society (ACS) Conference in San Francisco from August 10-14.  PerkinElmer has 2 booths across from each other (#1316 & #1317), and 8 total talks, with 3 of the talks in the field of informatics.

 

PerkinElmer will showcase 4 informatics products, that all have ChemDraw® embedded in them for easy chemical structure and reaction drawing.The 4 products are:

  1. ChemDraw version 14 with a direct link to Scifinder®
  2. Elements, the new cloud-based electronic lab notebook
  3. TIBCO Spotfire® for Lead Discovery for chemists
  4. PerkinElmer thick-client electronic lab notebook (E-Notebook).

  

 

-ChemDraw version 14, now with a direct link to SciFinder and ChemDraw for iPad®

In May, PerkinElmer launched ChemBioOffice® version 14, an integrated suite of personal productivity tools that enables chemists and biologists to capture, store, retrieve, and share data and information on compounds, reactions, materials, and their properties. ChemBioDraw now has a direct link to SciFinder®, which allows scientists to launch a literature search within the application, without time-consuming cutting and pasting of structures between different chemical and drawing tools.

 

ChemDraw® for iPad® provides all of the tools that scientists need to capture and share chemical inspiration and innovation- whenever and wherever. Scientists can quickly sketch a new scaffold, a synthetic pathway, or a compound, and share them with colleagues. ChemDraw for iPad features the revolutionary Flick-To-Share technology so that researchers, students, and teachers can immediately use their finger to “flick” chemical drawings to other iPad users within their network and receive modified structures back.

 


  • ACS TALK #378Technology will challenge the existing paradigm for teaching organic chemistry; 3-D printing, tablets, & gamification in Boston University’s Spring CH212.” Learn more about ChemDraw version 14 on August 12 at 11:35 AM in the Moscone Center North Building, Room 122. 

 

 

-Elements: a new Cloud-based electronic lab notebook from PerkinElmer

Elements is a zero-install, cloud-based electronic lab notebook delivered through a web browser that empowers scientists to easily capture scientific data, collaborate with colleagues, and search results and observations easily.  Elements has a modern user interface, is cost-effective, and has ChemDraw embedded for drawing chemical structures and calculating stoichiometry.

 

  • ACS TALK #412 Using a scientific collaboration platform, Elements, in teaching organic chemistry.” Learn more about our cloud-based electronic lab notebook Elements on August 12 at 3:05PM at the Moscone Center North Building, Room 122.  Dr. Layne Morsch from The University of Illinois Springfield will outline the university’s experience with Elements, as his students have been using Elements in his undergraduate organic chemistry lab for the past few months.

 

  

-TIBCO Spotfire® for Lead Discovery for Chemists

Chemists are continually asked to evaluate an increasing number of parameters that include chemical properties, biological assays and ADME results. TIBCO Spotfire for Lead Discovery software provides chemists with the capability to visualize their compound structures, and then group related compounds and associate compound structures to biological activity.  Medicinal chemists can investigate structure activity relationships (SAR) and explore the available compound library, searching by structures chosen from visualizations of available data or structure searches. Computational chemists can visualize and explore chemical scaffolds and compound library motifs in order to improve the design of compound libraries. ChemDraw is embedded in TIBCO Spotfire for Lead Discovery.

 

  • ACS TALK # 10 Structuring the unstructured: Creating knowledge through visual analytics and the use of TIBCO Spotfire with Attivio for text analytics of scientific patents.” Learn more about TIBCO Spotfire for Lead Discovery on August 10 at 11:35 AM at the Palace Hotel in the Presidio Room

 

 

-PerkinElmer E-Notebook for Chemistry

E-Notebook for Chemistry meets the needs of research chemists in all industries, enhancing personal productivity and improving data quality, while also protecting intellectual property and creating a sharable archive to foster collaboration and innovation. ChemBioDraw is embedded in the E-Notebook, which enables chemists to draw reactions and have the E-Notebook automatically calculate specific values.

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  • Learn about all of these products at Booth #1316 at ACS.

DIA 2014 50th Annual Meeting: Celebrate the Past - Invent the Future

by PerkinElmer Informatics12. June 2014 12:21

Join PerkinElmer at the DIA conference in San Diego from June 15-19 at Booth #512. The DIA (Drug Information Association) Conference focuses on clinical research, and brings together scientific professionals involved in the discovery, development, and life cycle management of medical products. The common goal is to foster innovation that will lead to the development of safe and effective medical products for patients.

Monitor with streamlined reports

Monitor the progress of your clinical trial by using streamlined reports that can help you accelerate your data review process, identify bottlenecks at real-time and address issues timely.

At PerkinElmer, we are striving to help clinical researchers with the visualization, reporting and collaboration of their data through TIBCO Spotfire. TIBCO Spotfire helps researchers with clinical safety review reports, the monitoring of adverse events, mapping clinical research locations, reviewing risk-based monitoring, examining trial operations, and pharmacovigilance.  Please email Nicoleta Economou to schedule a meeting at DIA, or for an on-site meeting and demonstration of TIBCO Spotfire for clinical research at Nicoleta.Economou@PERKINELMER.COM

 

Click here for more information regarding PerkinElmer Clinical and TIBCO Spotfire. 

 

 

Get better and faster insight into data

Get better and faster insight into your medical data to assess early on drug efficacy and safety.

 

 

Click here for a full list of 2014 PerkinElmer Informatics Events

Agricultural data visualization: Managing crop production through Spotfire®

by PerkinElmer Informatics30. May 2014 14:15

Photo Credit: Ian Sane via Compfight cc

TIBCO Spotfire® data visualization software isn’t just useful to chemists and biologists – it has a wide range of applications including QA/QC and productivity analysis.

For the agricultural industry, TIBCO Spotfire visualizations can help reveal important trends that effect changes to crop production and yields.  Spotfire allows many different variables such as environmental factors, geographic location yield percentage, types of products, seed care data, and insect control information to be brought together in a single platform and analyzed through intuitive visualizations.

For agricultural companies that operate in locations all over the world, Spotfire allows for everyone to access shared data in a single platform, promoting communications throughout the company and allowing coordinators and employees to be involved in the company’s goals.

Especially for companies that have many field-based employees, being able to look at comprehensive, shared-access project progress could be of great value. It would, for example, be much easier to quickly see where and how many acres are the most productive in a certain region, allowing for crop yields to be better understood and managed.

With projections estimating that crop production needs to double in the next decade to keep up with rising demands for food, agricultural productivity is more important than ever. Take a look at this demo we’ve put together – the dashboard was created to analyze corn production. It’s a great example of just how much agricultural insight can be unlocked through the power of data visualization.

ACRP Global Conference: Spotfire demos for clinical research

by PerkinElmer Informatics26. April 2014 12:55

Come and meet the PerkinElmer team at the Association of Clinical Research Professionals Global Conference and Exhibition, held April 26-29 in San Antonio, Texas!

Visit us at booth #540 and see how to improve the performance of your clinical trial by simplifying data access, integration and analysis with the TIBCO™  Spotfire® platform. We will be demonstrating how you can quickly and easily associate and observe trends in clinical datasets as well as identify issues early on for proactive and responsive decision-making.

Spotfire screen 1: Accelerate the medical and safety review process by bringing adverse event, labs, and concomitant medication data into a single platform.

Spotfire screen 2: Monitor the progress of your clinical trial, identify roadblocks and address issues timely using streamlined reports.

Scientific Showcase: San Jose event to highlight industry applications of Spotfire

by PerkinElmer Informatics25. April 2014 14:52

Photo Credit: Matteo Bagnoli via Compfight cc

 

We’re excited to be presenting a Scientific Showcase of how members of the scientific community have been putting the TIBCO Spotfire® visualization and analysis platform to work, discovering more insights and making better decisions in areas such as translational medicine, high content screening, clinical research, gene expression, chemistry and SAR analyses.

The Scientific Showcase will be part of our May 6 all-day Spotfire Day event, to be held in San Jose, California. In addition to the showcase, PerkinElmer Informatics and Spotfire experts will also be presenting strategies and case studies for how data visualization helps analyze and share research.

Showcase presentations will include the following:

Five Prime Therapeutics: A Fully Integrated Informatics Platform for Biologics Based High Throughput Screening

Presenter John Lin, Senior Software Engineer at Five Prime Therapeutics, will present an integrated system for managing informatics workflows and biologics-based screening for high throughput screening campaigns. High throughput screening is a key tool used to help identify lead molecules and targets during drug discovery processes. Lin will discuss how an integrated system, which includes plate management and logistics, assay registration, raw data capture and Spotfire data visualization, analysis and reporting, allows users to quickly turn raw data into scientific knowledge and decisions.

Amgen: Using Spotfire with High Content Imaging in Discovery Research: Quality Control, Data Mining, and Hit Review

With biopharmaceutical companies frequently performing large-scale high content screening efforts to identify genes or pathways that can be manipulated to impact disease progression, researchers need to exercise measures of quality control to make sure that large datasets comprising images and numerical descriptors are resulting in true results, and not results generated from imaging artifacts. Presenter Dr. Christopher Hale, discovery technology scientist at Amgen, will show how the Spotfire platform allows researchers to perform quality control analysis, visualize a more comprehensive view of a gene’s biological function, streamline hit selection, and validate selected phenotypes with rapid image retrieval.

Cytokinetics: Seeing is Believing – “Big Data” Management and Analysis

By using several examples of how data visualization tools can perform quality control and troubleshooting analysis rapidly and efficiently, presenter Dr. Julia Schaletzky, Senior Group Leader at Cytokinetics, will discuss how her group has made the Spotfire platform an integral part of its workflow. Data visualization allows for effective management and analysis of weekly lead optimization assays and for processing hits from large primary screenings.

Merck: An Enhanced Electronic Laboratory Notebook Integrated with Spotfire to Support Biologics Research and Development at Multiple Levels

Merck has transitioned its use of electronic laboratory notebooks from simply being a paper replacement to becoming an integrated platform that provides structure to data and results, carries out LIMS-like capabilities, and enables high-powered search and analytics functions and queries. Presenter Charlie Chang, Business and Technical Analyst at Merck Research Lab IT, will share how Merck is supporting its biologics research and development by leveraging the Spotfire analysis platform to assist in data visualization and aggregation.

It’s not too late to join us on May 6! If you’re interested in attending our complimentary Spotfire Day in San Jose, California, please click here to register.

Sustainable science: Earth Day tips for a green laboratory

by PerkinElmer Informatics22. April 2014 14:00

 

Photo Credit: Dominic's pics via Compfight cc

So much scientific research goes into discovering methods to increase energy creation and efficiency while minimizing environmental impact, but ironically laboratories themselves use up extremely high amounts of energy to maintain operation. This Earth Day, let's review several pointers to help make your laboratory more sustainable and environmentally friendly.

On average, research laboratories use four or five times more energy than office buildings. It’s not surprising given the amount of equipment and technology that laboratories employ. Devices like fumigators, exhaust devices and containment systems, heating and cooling equipment, building ventilation systems and back-up generator and emergency power units all draw heavy energy usage. In addition, laboratories are subject to around-the-clock operation as scientists need 24/7 access to carry out their experiments.

Research facilities hoping to increase energy efficiency and sustainability can decrease electricity usage through simple steps like remembering to power off equipment that is not in use, disconnecting seldom-used equipment and remembering to turn off lights whenever a room is unoccupied.

More aggressive energy conservation efforts can be taken to optimize water usage by selecting low-flow faucets and water retention systems. Natural sunlight can be captured through rooftop and building-side photovoltaic panels so that laboratories can generate self-sustaining electricity. Airflow systems use a lot of energy to provide heating and cooling throughout laboratories; special window treatments and roofing can be used to leverage natural sunlight. Changes can be made to the heating and cooling system to reduce energy waste. PerkinElmer’s Santa Clara data center implemented an airflow optimization project that reduced annual energy usage by 69,000 kilowatt hours through the elimination of unnecessary overcooling.           

Laboratory employees should also maintain careful inventory records to avoid over-purchasing which can contribute to waste. Once products are ordered, stock chemicals and reagents should be used in the chronological order in which they were purchased. The purchasing of recycled products should be encouraged whenever possible, and supply managers should select vendors that participate in equipment buy-back programs. Inventory management can be achieved through diligent record keeping, but laboratory managers are also wise to invest in inventory management software that will help make automated, real-time decisions about the quantity and frequency of ordering new materials.

Laboratories can also opt to participate in organizations such as the Carbon Disclosure Project and the EPA’s Green Power Partnership to promote and contribute to the awareness of sustainable practices.

You can read more about specific ways to establish more environmentally-friendly, energy-efficient and sustainable laboratory practices here:

Green chemistry made easy: Simple ELN configurations

Sustainable science: Reducing the environmental stress of research

Informatics for a greener tomorrow: Guidelines and solutions

It’s basic biology: How data visualization is improving translational medicine

by PerkinElmer Informatics9. April 2014 15:17

 Photo Credit: JohnGoode via Compfight cc

For researchers and practitioners of translational and personalized medicine, implementing effective diagnosis and treatment methods is all about bringing together novel and diverse data and being able to draw meaningful insights from that information.

It’s been well established that not all patients will respond the same way to the same drugs, but the challenge is figuring out exactly which factors impact a drug’s efficacy within an individual’s body. The only way to flush out patterns and correlations among patient populations is to compare mass amounts of diverse data. Even after carrying out data reductions, all these data sets are still different types of data – the solution is finding a tool that is capable of bringing all of this information together and integrating it in a coordinated fashion.

The end goal is that from this data integration, insights can then be revealed. While software programs can perform the heavy lifting parts of data crunching and analysis, it still requires a human operator to explore and identify potential areas of correlation. Data mining of patient populations cannot be done without a scientist first asking: how, why, what, when, who?

Biologically, humans are well wired for exceptional visual analysis. Our optic nerve can transfer incoming visual data to our brains as fast as an Ethernet connection. Once received in the brain, evolution has honed our abilities to distinguish shapes, edges, and boundaries, and to identify patterns from that visual data – all almost instantaneously.

When it comes to working with data sets, it’s our pattern matching ability that makes data visualization such an effective analysis tool. As data is portrayed visually, we can quickly distinguish differences in shapes and patterns between sets much more quickly than we would be able to do by looking at numbers alone.  Visualization gives meaning and context to data that would otherwise be vast compilations of numbers, facts and measurements.

For many scientists in the clinical and life sciences market, the TIBCO Spotfire® data visualization software platform has already been a helpful tool for understanding data. Many users have already implemented their own best practices strategies for using visual analysis tactics in data mining. However, through our exclusive agreement with TIBCO, Inc., our Informatics team is now focused on developing software templates and add-ons that will cater specifically to the life sciences industry.

Over the next several years, as data visualization becomes a best practices standard for analysis of data in clinical and life sciences research, one of the biggest changes we can hope to see will be the advent of the application of next generation sequencing in the clinic. When it comes to understanding diseases like cancer, scientists will be able to diagnose types of cancer instead of locations of cancer, narrowing down treatment options that are most likely to be effective against a certain cancer’s type.  Visualization software will be used return better diagnoses, to recommend more specific therapies, and to even provide guidance for illness prevention.

To learn more about data visualization and Spotfire, consider attending our Dr. Spotfire Day on May 6in San Jose, California.

Our guide to ACS Dallas: ChemDraw® + SciFinder®, collaborating in the cloud, and why Spotfire® matters

by PerkinElmer Informatics11. March 2014 10:02

SciFinder® and ChemDraw® have united to empower scientists.

We've entered the homestretch of the countdown to ACS Dallas, the 247th American Chemical Society National Meeting and Exposition, which is to be held March 16-20 in Dallas, Texas. The PerkinElmer Informatics team is not only excited to attend, but also to present the latest product developments that we've been working on this year. Here's a preview of what you can expect to see and hear from PKI Informatics at ACS Dallas:

ChemDraw® + SciFinder®

Our Informatics team is thrilled to preview our integration of SciFinder® into ChemBioDraw Ultra®, which we've been developing in collaboration with Chemical Abstracts Service, the provider of SciFinder. We'll be presenting the integration and demonstrating its capabilities in the ACS Village at 3:00pm on Monday, March 17, and 11:00AM on Tuesday, March 18. Attend a session to see how you can get answers sooner and increase your productivity now that our scientific drawing program has united with the world's largest database of scientific and chemical information.

ChemDraw for iPad®

Our ChemDraw for iPad® app has been a big hit, earning an honorable mention from The Scientist magazine for the Top Ten Innovations of 2013. Join Dr. Layne Morsch of the University of Illinois Springfield on Tuesday, March 18, at 8:55am in the Hyatt Regency Dallas Reunion Ballroom G to learn how ChemDraw is fostering increased engagement in organic chemistry education.

Collaborating in the cloud

Register to preview the next big thing in science on Monday, March 17, from 12:30-3:00pm in the Dallas Convention Center, room D220, when our team will demonstrate how simplicity and cloud technology will redefine electronic laboratory notebooks with the launch of our new collaborative science platform. Or attend a 5:00pm session on Tuesday, March 18, in the Omni Dallas Hotel, Deep Ellum A, to hear directly from one of our beta users.

Why Spotfire® Matters

Come see why the TIBCO Spotfire® data visualization and analysis platform (example pictured above) "matters" in rheology, nanoscience, and renewable resources research. If you have ever struggled to uncover trends and patterns from a sea of data, we will show you how to unlock insights through the power of visualization software. Hear Dr. Josh Bishop speak on Monday, March 17, at 2:15pm in Omni Dallas Hotel, Deep Ellum A, on optimizing catalyst development by using Spotfire to mine ELN-based structured test results and chemical property data.

Visit us throughout ACS Dallas in booth #1508 to learn more about any of these products and to meet our team. We are looking forward to seeing you in Dallas!

TIBCO Spotfire® Goes Back To Its Roots: An Interactive Periodic Table

by Philip Skinner7. March 2014 10:33

In 1991, Christopher Ahlberg was a visiting student working in the University of Maryland's Human-Computer Interaction Laboratory under the direction of Ben Shneiderman. Professor Shneiderman tasked Christopher with building an early application that would allow dynamic queries on data to be controlled by the end user through the adjustment of sliders, buttons, check boxes, and other widgets. This was a departure from traditional command line interfaces and provided end users with a more visual, interactive and intuitive interface. Christopher, for his first such application, built a tool for querying the data associated with the periodic table. From this early foray into data analytics, the TIBCO Spotfire data visualization and analysis platform was born, and was soon being used to support varied data querying common in lifescience and pharmaceutical research. Today, the software program is used by most, if not all, major pharmaceutical organizations.

PerkinElmer Informatics, the home of software solutions such as ChemDraw and the industry leading E-Notebook, embarked on a joint partnership with TIBCO Software™ in 2012. TIBCO had acquired Spotfire in the years following its creation and guided it to be a leading analytics and business intelligence tool. By striking two partnership agreements with TIBCO, PerkinElmer has become the provider and developer of the TIBCO Spotfire platform as a visualization and analysis tool in science.

One of the virtues of Spotfire is that although it allows for advanced users, or analysts, to query the data in virtually any manner they want, it also allows for much simpler, predefined queries to be run through a web browser by more occasional users. The PerkinElmer Informatics team was interested in finding fun applications of Spotfire that would help communicate what exactly Spotfire does through this web browser.

Ironically (or perhaps not so ironically), the Informatics team decided on creating an interactive Periodic Table as a fun demo for use by scientists and students, just as Christopher Ahlberg used in 1991 as Spotfire’s first application.

Were you ever interested in who discovered the most elements, or what the relative abundance of an element is in seawater or in the human body? This online tool allows you to easily select portions of the periodic table and rapidly and intuitively display information that is dynamically updated on the basis of selections that you make.

In this hands-on interactive tool, anyone can create a number of visualizations based on chemical and physical property data of the elements, presented via a Periodic Table. Users can select parts of the table and display the relative abundance of only the selected atoms in dynamic pie charts, or show graphs depicting the age or country of discovery, along with headshots of the discovers.

You can access the interactive periodic table here. This visualization forms part of a broader gallery of freely available online demonstrations which you can find here. And, if you care to try out TIBCO Spotfire® for yourself, you can download a free trial to see how Spotfire can help you with your data challenges right here.

Spotlight on science: Study reveals the brain's white matter "scaffold" of connections

by PerkinElmer Informatics21. February 2014 13:12

 Image credit: USC Institute of Neurology and Informatics

Neuroscientists have introduced new terminology to describe the brain’s connective neural pathways after completing a study that used social network models to analyze the brain’s communication network. Researchers at USC Institute for Neurology and Informatics are now calling the brain’s network of white matter a “scaffold” of connections through which the brain operates.

“We coined the term white matter ‘scaffold’ because this network defines the information architecture which supports brain function,” researcher John Darrell Van Horn was quoted as saying in USC’s press release on the study. Van Horn was a senior author on the article describing the study, which was published in Frontiers in Human Neuroscience on February 11.

While the potential consequences of brain injuries to gray matter are better known, it is not yet well understood just how injuries to white matter affect the brain’s network properties.

To study the effects, USC researchers used MRI data from 110 individuals to analyze simulations of brain injury to white matter pathways. The results were then analyzed through comparison to social network models, which document how large networks of social ties are affected by individual damaged relationships. Researchers specifically focused on understanding how strong the connections between neurons are, revealing instances in which certain connections demonstrated higher sensitivity to injury and instances in which damage to one connection led to a catastrophic ripple effect, resulting in disconnection of a large number of communication pathways.

By using the application of a social network model to analyze the effects of simulated brain injury, the USC Neurology and Informatics team was able to observe connective damage within the context of a larger communications network. The results of the study help to explain why brain injuries have been so unpredictable until this point – such as when some people experience severe brain trauma but can make a full recovery, while others suffer a seemingly small injury but experience irreversible and life-altering loss of brain functions.

The results of this study on the white matter "scaffold" have big implications for the diagnosis and treatment of degenerative neurological diseases and traumatic brain injuries, and contribute to a worldwide effort led by the Human Connectome Project and the Laboratory of Neuro Imaging at USC to map all 100 billion neurons and 1,000 trillion connections in the human brain.

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